Role of Orexin in Respiratory and Sleep Homeostasis during Upper Airway Obstruction in Rats | Zendy

Ariel Tarasiuk | Zendy; Avishag Levi | Zendy; Nilly Berdugo-Boura | Zendy; Ari Yahalom | Zendy; Yael Segev | Zendy

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Role of Orexin in Respiratory and Sleep Homeostasis during Upper Airway Obstruction in Rats

Author(s) -

Ariel Tarasiuk,

Avishag Levi,

Nilly Berdugo-Boura,

Ari Yahalom,

Yael Segev

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3676

Subject(s) - sleep (system call) , orexin , respiratory system , airway , medicine , homeostasis , airway obstruction , anesthesia , neuroscience , endocrinology , psychology , neuropeptide , receptor , computer science , operating system

Chronic upper airway obstruction (UAO) elicits a cascade of complex endocrine derangements that affect growth, sleep, and energy metabolism. We hypothesized that elevated hypothalamic orexin has a role in maintaining ventilation during UAO, while at the same time altering sleep-wake activity and energy metabolism. Here, we sought to explore the UAO-induced changes in hypothalamic orexin and their role in sleep-wake balance, respiratory activity, and energy metabolism.

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