The Complex Sleep Apnea Resolution Study: A Prospective Randomized Controlled Trial of Continuous Positive Airway Pressure Versus Adaptive Servoventilation Therapy | Zendy

Timothy I. Morgenthaler | Zendy; Tomasz J. Kuźniar | Zendy; Lisa F. Wolfe | Zendy; Leslee Willes | Zendy; William C. McLain | Zendy; Rochelle Goldberg | Zendy

Open Access

The Complex Sleep Apnea Resolution Study: A Prospective Randomized Controlled Trial of Continuous Positive Airway Pressure Versus Adaptive Servoventilation Therapy

Author(s) -

Timothy I. Morgenthaler,

Tomasz J. Kuźniar,

Lisa F. Wolfe,

Leslee Willes,

William C. McLain,

Rochelle Goldberg

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3662

Subject(s) - continuous positive airway pressure , medicine , randomized controlled trial , epworth sleepiness scale , sleep apnea , obstructive sleep apnea , polysomnography , anesthesia , apnea–hypopnea index , positive airway pressure , apnea , positive pressure

Prior studies show that adaptive servoventilation (ASV) is initially more effective than continuous positive airway pressure (CPAP) for patients with complex sleep apnea syndrome (CompSAS), but choosing therapies has been controversial because residual central breathing events may resolve over time in many patients receiving chronic CPAP therapy. We conducted a multicenter, randomized, prospective trial comparing clinical and polysomnographic outcomes over prolonged treatment of patients with CompSAS, with CPAP versus ASV.

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