Eszopiclone and Dexmedetomidine Depress Ventilation in Obese Rats with Features of Metabolic Syndrome | Zendy

William A. Filbey | Zendy; David T. Sanford | Zendy; Helen A. Baghdoyan | Zendy; Lauren G. Koch | Zendy; Steven L. Britton | Zendy; Ralph Lydic | Zendy

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Eszopiclone and Dexmedetomidine Depress Ventilation in Obese Rats with Features of Metabolic Syndrome

Author(s) -

William A. Filbey,

David T. Sanford,

Helen A. Baghdoyan,

Lauren G. Koch,

Steven L. Britton,

Ralph Lydic

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3650

Subject(s) - dexmedetomidine , anesthesia , sedative , medicine , hypnotic , respiratory minute volume , tidal volume , ventilation (architecture) , respiratory rate , agonist , respiratory system , sedation , heart rate , blood pressure , receptor , mechanical engineering , engineering

Obesity alters the therapeutic window of sedative/hypnotic drugs and increases the probability of respiratory complications. The current experiments used an established rodent model of obesity to test the hypothesis that the sedative/hypnotic drugs eszopiclone and dexmedetomidine alter ventilation differentially in obese rats compared with lean/fit rats.

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