Trazodone Increases the Respiratory Arousal Threshold in Patients with Obstructive Sleep Apnea and a Low Arousal Threshold | Zendy

Danny J. Eckert | Zendy; Atul Malhotra | Zendy; Andrew Wellman | Zendy; David P. White | Zendy

Open Access

Trazodone Increases the Respiratory Arousal Threshold in Patients with Obstructive Sleep Apnea and a Low Arousal Threshold

Author(s) -

Danny J. Eckert,

Atul Malhotra,

Andrew Wellman,

David P. White

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3596

Subject(s) - dilator , arousal , anesthesia , medicine , trazodone , genioglossus , obstructive sleep apnea , apnea , continuous positive airway pressure , respiratory system , breathing , low arousal theory , sleep and breathing , sleep apnea , cardiology , psychology , antidepressant , neuroscience , hippocampus

The effect of common sedatives on upper airway physiology and breathing during sleep in obstructive sleep apnea (OSA) has been minimally studied. Conceptually, certain sedatives may worsen OSA in some patients. However, sleep and breathing could improve with certain sedatives in patients with OSA with a low respiratory arousal threshold. This study aimed to test the hypothesis that trazodone increases the respiratory arousal threshold in patients with OSA and a low arousal threshold. Secondary aims were to examine the effects of trazodone on upper airway dilator muscle activity, upper airway collapsibility, and breathing during sleep.

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