Role of Adenosine and the Orexinergic Perifornical Hypothalamus in Sleep-Promoting Effects of Ethanol | Zendy

Rishi Sharma | Zendy; Pradeep Sahota | Zendy; Mahesh Thakkar | Zendy

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Role of Adenosine and the Orexinergic Perifornical Hypothalamus in Sleep-Promoting Effects of Ethanol

Author(s) -

Rishi Sharma,

Pradeep Sahota,

Mahesh Thakkar

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3490

Subject(s) - orexin , lateral hypothalamus , orexin receptor , medicine , endocrinology , wakefulness , hypothalamus , adenosine , chemistry , orexin a , sleep (system call) , receptor , psychology , neuroscience , neuropeptide , electroencephalography , computer science , operating system

Strong clinical and preclinical evidence suggests that acute ethanol promotes sleep. However, very little is known about how and where ethanol acts to promote sleep. We hypothesized that ethanol may induce sleep by increasing extracellular levels of adenosine and inhibiting orexin neurons in the perifornical hypothalamus.

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