Effects of Chronic Sleep Fragmentation on Wake-Active Neurons and the Hypercapnic Arousal Response | Zendy

Yanpeng Li | Zendy; Lori A. Panossian | Zendy; Jing Zhang | Zendy; Yan Zhu | Zendy; Guanxia Zhan | Zendy; Yu-Ting Chou | Zendy; Polina Fenik | Zendy; Seema Bhatnagar | Zendy; David Piel | Zendy; Sheryl G. Beck | Zendy; Sigrid C. Veasey | Zendy

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Effects of Chronic Sleep Fragmentation on Wake-Active Neurons and the Hypercapnic Arousal Response

Author(s) -

Yanpeng Li,

Lori A. Panossian,

Jing Zhang,

Yan Zhu,

Guanxia Zhan,

Yu-Ting Chou,

Polina Fenik,

Seema Bhatnagar,

David Piel,

Sheryl G. Beck,

Sigrid C. Veasey

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3306

Subject(s) - locus coeruleus , arousal , hypercapnia , medicine , endocrinology , sleep deprivation , psychology , anesthesia , neuroscience , circadian rhythm , respiratory system , central nervous system

Delayed hypercapnic arousals may occur in obstructive sleep apnea. The impaired arousal response is expected to promote more pronounced oxyhemoglobin desaturations. We hypothesized that long-term sleep fragmentation (SF) results in injury to or dysfunction of wake-active neurons that manifests, in part, as a delayed hypercapnic arousal response.

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