DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe | Zendy

Mehdi Tafti | Zendy; Hyun Hor | Zendy; Yves Dauvilliers | Zendy; Gert Jan Lammers | Zendy; Sebastiaan Overeem | Zendy; Geert Mayer | Zendy; Sirous Javidi | Zendy; Álex Iranzo | Zendy; Joan Santamaría | Zendy; Rosa PeraitaAdrados | Zendy; José L. Vicário | Zendy; Isabelle Arnulf | Zendy; Giuseppe Plazzi | Zendy; Sophie Bayard | Zendy; Francesca Poli | Zendy; Fabio Pizza | Zendy; Peter Geisler | Zendy; Aleksandra Wierzbicka | Zendy; Claudio L. Bassetti | Zendy; Johannes Mathis | Zendy; Michel Lecendreux | Zendy; Claire E. H. M. Donjacour | Zendy; Astrid van der Heide | Zendy; Raphaël Heinzer | Zendy; José HabaRubio | Zendy; Eva Feketeová | Zendy; Birgit Högl | Zendy; Birgit Frauscher | Zendy; Antonio Benetó | Zendy; Ramin Khatami | Zendy; Francesca Cañellas | Zendy; Corinne Pfister | Zendy; Sabine Scholz | Zendy; Michel Billiard | Zendy; Christian R. Baumann | Zendy; Guadalupe Ercilla | Zendy; Willem Verduijn | Zendy; Frans H.J. Claas | Zendy; Valérie Dubois | Zendy; Jacek Nowak | Zendy; Hans-Peter Eberhard | Zendy; Sylvain Pradervand | Zendy; Charlotte N. Hor | Zendy; Manuela Testi | Zendy; J.-M. Tiercy | Zendy; Zoltán Kutalik | Zendy

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DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe

Author(s) -

Mehdi Tafti,

Hyun Hor,

Yves Dauvilliers,

Gert Jan Lammers,

Sebastiaan Overeem,

Geert Mayer,

Sirous Javidi,

Álex Iranzo,

Joan Santamaría,

Rosa PeraitaAdrados,

José L. Vicário,

Isabelle Arnulf,

Giuseppe Plazzi,

Sophie Bayard,

Francesca Poli,

Fabio Pizza,

Peter Geisler,

Aleksandra Wierzbicka,

Claudio L. Bassetti,

Johannes Mathis,

Michel Lecendreux,

Claire E. H. M. Donjacour,

Astrid van der Heide,

Raphaël Heinzer,

José HabaRubio,

Eva Feketeová,

Birgit Högl,

Birgit Frauscher,

Antonio Benetó,

Ramin Khatami,

Francesca Cañellas,

Corinne Pfister,

Sabine Scholz,

Michel Billiard,

Christian R. Baumann,

Guadalupe Ercilla,

Willem Verduijn,

Frans H.J. Claas,

Valérie Dubois,

Jacek Nowak,

Hans-Peter Eberhard,

Sylvain Pradervand,

Charlotte N. Hor,

Manuela Testi,

J.-M. Tiercy,

Zoltán Kutalik

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3300

Subject(s) - narcolepsy , cataplexy , odds ratio , single nucleotide polymorphism , hla dqb1 , genome wide association study , human leukocyte antigen , locus (genetics) , genetics , allele , medicine , psychology , biology , psychiatry , genotype , modafinil , gene , antigen

Prior research has identified five common genetic variants associated with narcolepsy with cataplexy in Caucasian patients. To replicate and/or extend these findings, we have tested HLA-DQB1, the previously identified 5 variants, and 10 other potential variants in a large European sample of narcolepsy with cataplexy subjects.

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