A Pro-Inflammatory Role for Nuclear Factor Kappa B in Childhood Obstructive Sleep Apnea Syndrome | Zendy

Lee P. Israel | Zendy; Daniel Benharoch | Zendy; Jacob Gopas | Zendy; Aviv D. Goldbart | Zendy

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A Pro-Inflammatory Role for Nuclear Factor Kappa B in Childhood Obstructive Sleep Apnea Syndrome

Author(s) -

Lee P. Israel,

Daniel Benharoch,

Jacob Gopas,

Aviv D. Goldbart

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3236

Subject(s) - nfkb1 , relb , transcription factor , obstructive sleep apnea , p50 , tumor necrosis factor alpha , nf κb , microbiology and biotechnology , reporter gene , chemistry , biology , medicine , endocrinology , inflammation , gene expression , gene , biochemistry

Childhood obstructive sleep apnea syndrome (OSAS) is associated with an elevation of inflammatory markers such as C-reactive protein (CRP) that correlates with specific morbidities and subsides following intervention. In adults, OSAS is associated with activation of the transcription factor nuclear factor kappa B (NF-kB). We explored the mechanisms underlying NF-kB activation, based on the hypothesis that specific NF-kB signaling is activated in children with OSAS.

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