Open AccessAssociation of Restless Legs Syndrome Variants in Korean Patients with Restless Legs Syndrome
Author(s) -
Myeong-Kyu Kim,
Yong Won Cho,
Won Chul Shin,
Jae Wook Cho,
Young Min Shon,
Jee Hyun Kim,
Kwang Ik Yang,
Christopher J. Earley,
Richard P. Allen
Publication year - 2013
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.3200
Subject(s) - restless legs syndrome , genome wide association study , odds ratio , single nucleotide polymorphism , pathogenesis , allele , genetics , epistasis , genetic association , genotype , medicine , snp , population , disease , biology , gene , psychiatry , neurology , environmental health
Recent genome-wide association studies (GWAS) for Caucasians identified several allelic variants associated with increased risk of developing restless legs syndrome (RLS), also known as Willis-Ekbom disease. Although the pathogenic mechanisms of RLS are not entirely understood, it is becoming increasingly evident that many diseases such as RLS can be attributed to an epistasis. The study objectives were to evaluate whether the associations of RLS with all loci determined in previous GWAS for Caucasians can be replicated significantly for the Korean population and to elucidate whether an epistasis plays a role in the pathogenesis of RLS.
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