Obstructive Sleep Apnea, Excessive Daytime Sleepiness, and Morning Plasma TNF-α Levels in Greek Children | Zendy

Emmanouel Ι. Alexopoulos | Zendy; Vasiliki Theologi | Zendy; Georgia Malakasioti | Zendy; Panagiotis Maragozidis | Zendy; Irene Tsilioni | Zendy; George P. Chrousos | Zendy; Konstantinos I. Gourgoulianis | Zendy; Athanasios G. Kaditis | Zendy

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Obstructive Sleep Apnea, Excessive Daytime Sleepiness, and Morning Plasma TNF-α Levels in Greek Children

Author(s) -

Emmanouel Ι. Alexopoulos,

Vasiliki Theologi,

Georgia Malakasioti,

Panagiotis Maragozidis,

Irene Tsilioni,

George P. Chrousos,

Konstantinos I. Gourgoulianis,

Athanasios G. Kaditis

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3114

Subject(s) - obstructive sleep apnea , polysomnography , medicine , morning , body mass index , excessive daytime sleepiness , obesity , apnea , endocrinology , insomnia , sleep disorder , psychiatry

Obstructive sleep apnea (OSA) has been associated with increased frequency of excessive daytime sleepiness (EDS). Increased plasma TNF-α levels may mediate this association in adults, but conflicting results have been reported in children. We hypothesized that: (i) the higher the OSA severity in childhood, the higher the frequency of EDS and morning plasma TNF-α levels; and (ii) high TNF-α levels predict presence of EDS.

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