Antidepressants and REM Sleep Behavior Disorder: Isolated Side Effect or Neurodegenerative Signal? | Zendy

Ronald B. Postuma | Zendy; JeanFrançois Gag | Zendy; Maria Tuineaig | Zendy; JosieAnne Bertrand | Zendy; Véronique Latreille | Zendy; Catherine Desjardins | Zendy; Jacques Montplaisir | Zendy

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Antidepressants and REM Sleep Behavior Disorder: Isolated Side Effect or Neurodegenerative Signal?

Author(s) -

Ronald B. Postuma,

JeanFrançois Gag,

Maria Tuineaig,

JosieAnne Bertrand,

Véronique Latreille,

Catherine Desjardins,

Jacques Montplaisir

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3102

Subject(s) - rem sleep behavior disorder , medicine , polysomnography , prospective cohort study , depression (economics) , parkinson's disease , antidepressant , neurodegeneration , dementia , disease , apnea , hippocampus , economics , macroeconomics

Antidepressants, among the most commonly prescribed medications, trigger symptoms of REM sleep behavior disorder (RBD) in up to 6% of users. Idiopathic RBD is a very strong prodromal marker of Parkinson disease and other synuclein-mediated neurodegenerative syndromes. It is therefore critically important to understand whether antidepressant-associated RBD is an independent pharmacologic syndrome or a sign of possible prodromal neurodegeneration.

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