Obstructive Sleep Apnea is Associated with Preserved Bone Mineral Density in Healthy Elderly Subjects | Zendy

Émilia Sforza | Zendy; Thierry Thomas | Zendy; Jean Barthélemy | Zendy; Philippe Collet | Zendy; Frédéric Roche | Zendy

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Obstructive Sleep Apnea is Associated with Preserved Bone Mineral Density in Healthy Elderly Subjects

Author(s) -

Émilia Sforza,

Thierry Thomas,

Jean Barthélemy,

Philippe Collet,

Frédéric Roche

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.3046

Subject(s) - obstructive sleep apnea , medicine , bone mineral , sleep (system call) , sleep apnea , polysomnography , apnea , bone density , sleep apnea syndromes , cardiology , anesthesia , osteoporosis , computer science , operating system

Chronic intermittent hypoxia (IH) acts as a stimulator of mesenchymal stem cell (MSC) mobilization, intensifying osteoblast formation in animal models. The recurrence of apnea and oxygen desaturation in obstructive sleep apnea (OSA) may mimic experimental models of IH. We hypothesized that in elderly with OSA, apnea-related IH may mobilize MSCs and thereby prevent the age-related decline in osteogenesis. This study explored the relationship between OSA and bone mineral density (BMD), and the effect of IH on BMD, in a large sample of elderly subjects.

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