Vagotomy Attenuates Brain Cytokines and Sleep Induced by Peripherally Administered Tumor Necrosis Factor-α and Lipopolysaccharide in Mice | Zendy

Mark R. Zielinski | Zendy; Danielle Dunbrasky | Zendy; Ping Taishi | Zendy; Gianne Souza | Zendy; James M. Krueger | Zendy

Open Access

Vagotomy Attenuates Brain Cytokines and Sleep Induced by Peripherally Administered Tumor Necrosis Factor-α and Lipopolysaccharide in Mice

Author(s) -

Mark R. Zielinski,

Danielle Dunbrasky,

Ping Taishi,

Gianne Souza,

James M. Krueger

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.2892

Subject(s) - vagotomy , tumor necrosis factor alpha , medicine , endocrinology , lipopolysaccharide , cytokine , vagus nerve , rapid eye movement sleep , proinflammatory cytokine , stimulation , inflammation , electroencephalography , psychiatry

Systemic tumor necrosis factor-α (TNF-α) is linked to sleep and sleep altering pathologies in humans. Evidence from animals indicates that systemic and brain TNF-α have a role in regulating sleep. In animals, TNF-α or lipopolysaccharide (LPS) enhance brain pro-inflammatory cytokine expression and sleep after central or peripheral administration. Vagotomy blocks enhanced sleep induced by systemic TNF-α and LPS in rats, suggesting that vagal afferent stimulation by TNF-α enhances pro-inflammatory cytokines in sleep-related brain areas. However, the effects of systemic TNF-α on brain cytokine expression and mouse sleep remain unknown.

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