Energetic and Cell Membrane Metabolic Products in Patients with Primary Insomnia: A 31-Phosphorus Magnetic Resonance Spectroscopy Study at 4 Tesla | Zendy

David G. Harper | Zendy; David T. Plante | Zendy; J. Eric Jensen | Zendy; Caitlin Ravichandran | Zendy; Orfeu M. Buxton | Zendy; Kathleen L. Benson | Zendy; Shawn O’Connor | Zendy; Perry F. Renshaw | Zendy; John W. Winkelman | Zendy

Open Access

Energetic and Cell Membrane Metabolic Products in Patients with Primary Insomnia: A 31-Phosphorus Magnetic Resonance Spectroscopy Study at 4 Tesla

Author(s) -

David G. Harper,

David T. Plante,

J. Eric Jensen,

Caitlin Ravichandran,

Orfeu M. Buxton,

Kathleen L. Benson,

Shawn O’Connor,

Perry F. Renshaw,

John W. Winkelman

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.2530

Subject(s) - phosphocreatine , primary insomnia , polysomnography , medicine , white matter , actigraphy , endocrinology , sleep onset , psychology , sleep disorder , psychiatry , insomnia , magnetic resonance imaging , energy metabolism , circadian rhythm , apnea , radiology

Primary insomnia (PI) is a sleep disorder characterized by difficulty with sleep initiation, maintenance, and/or the experience of nonrestorative sleep combined with a subsequent impairment of daytime functioning. The hyperarousal hypothesis has emerged as the leading candidate to explain insomnia symptoms in the absence of specific mental, physical, or substance-related causes. We hypothesized that the cellular energetic metabolites, including beta nucleoside triphosphate, which in magnetic resonance spectroscopy approximates adenosine triphosphate (ATP), and phosphocreatine (PCr), would show changes in PI reflecting increased energy demand.

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