Extrasynaptic GABAA Receptors in Rat Pontine Reticular Formation Increase Wakefulness | Zendy

Giancarlo Vanini | Zendy; Helen A. Baghdoyan | Zendy

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Extrasynaptic GABAA Receptors in Rat Pontine Reticular Formation Increase Wakefulness

Author(s) -

Giancarlo Vanini,

Helen A. Baghdoyan

Publication year - 2013

Publication title -

sleep

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.2444

Subject(s) - gabaa receptor , paramedian pontine reticular formation , neuroscience , wakefulness , reticular formation , pons , reticular activating system , reticular connective tissue , receptor , psychology , medicine , electroencephalography , anatomy , central nervous system

Gamma-aminobutyric acid (GABA) causes phasic inhibition via synaptic GABAA receptors and tonic inhibition via extrasynaptic GABAA receptors. GABA levels in the extracellular space regulate arousal state and cognition by volume transmission via extrasynaptic GABAA receptors. GABAergic transmission in the pontine reticular formation promotes wakefulness. No previous studies have determined whether an agonist at extrasynaptic GABAA receptors administered into the pontine reticular formation alters sleep and wakefulness. Therefore, this study used gaboxadol (THIP; agonist at extrasynaptic GABAA receptors that contain a δ subunit) to test the hypothesis that extrasynaptic GABAA receptors within the pontine reticular formation modulate sleep and wakefulness.

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