Homeostatic and Circadian Contribution to EEG and Molecular State Variables of Sleep Regulation | Zendy

Thomas Curie | Zendy; Valérie Mongrain | Zendy; Stéphane Dorsaz | Zendy; Géraldine M. Mang | Zendy; Yann Emmenegger | Zendy; Paul Franken | Zendy

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Homeostatic and Circadian Contribution to EEG and Molecular State Variables of Sleep Regulation

Author(s) -

Thomas Curie,

Valérie Mongrain,

Stéphane Dorsaz,

Géraldine M. Mang,

Yann Emmenegger,

Paul Franken

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.2440

Subject(s) - circadian rhythm , sleep (system call) , electroencephalography , psychology , free running sleep , neuroscience , sleep deprivation , medicine , circadian clock , computer science , light effects on circadian rhythm , operating system

Besides their well-established role in circadian rhythms, our findings that the forebrain expression of the clock-genes Per2 and Dbp increases and decreases, respectively, in relation to time spent awake suggest they also play a role in the homeostatic aspect of sleep regulation. Here, we determined whether time of day modulates the effects of elevated sleep pressure on clock-gene expression. Time of day effects were assessed also for recognized electrophysiological (EEG delta power) and molecular (Homer1a) markers of sleep homeostasis.

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