Acetazolamide Attenuates the Ventilatory Response to Arousal in Patients with Obstructive Sleep Apnea | Zendy

Bradley A. Edwards | Zendy; James G. Connolly | Zendy; Lisa M. Campana | Zendy; Scott A. Sands | Zendy; John A. Trinder | Zendy; David P. White | Zendy; Andrew Wellman | Zendy; Atul Malhotra | Zendy

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Acetazolamide Attenuates the Ventilatory Response to Arousal in Patients with Obstructive Sleep Apnea

Author(s) -

Bradley A. Edwards,

James G. Connolly,

Lisa M. Campana,

Scott A. Sands,

John A. Trinder,

David P. White,

Andrew Wellman,

Atul Malhotra

Publication year - 2013

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.2390

Subject(s) - acetazolamide , medicine , anesthesia , arousal , ventilation (architecture) , apnea , respiratory minute volume , tidal volume , sleep and breathing , obstructive sleep apnea , respiratory system , psychology , mechanical engineering , neuroscience , engineering

The magnitude of the post-apnea/hypopnea ventilatory overshoot following arousal may perpetuate subsequent respiratory events in obstructive sleep apnea (OSA) patients, potentially contributing to the disorder's severity. As acetazolamide can reduce apnea severity in some patients, we examined the effect of acetazolamide on the ventilatory response to spontaneous arousals in CPAP-treated OSA patients.

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