Deep Brain Stimulation of Pedunculopontine Tegmental Nucleus: Role in Sleep Modulation in Advanced Parkinson Disease Patients—One-Year Follow-Up | Zendy

Antonella Peppe | Zendy; Mariangela Pierantozzi | Zendy; Valentina Baiamonte | Zendy; Vincenzo Moschella | Zendy; Carlo Caltagirone | Zendy; Paolo Stanzione | Zendy; Alessandro Stefani | Zendy

Open Access

Deep Brain Stimulation of Pedunculopontine Tegmental Nucleus: Role in Sleep Modulation in Advanced Parkinson Disease Patients—One-Year Follow-Up

Author(s) -

Antonella Peppe,

Mariangela Pierantozzi,

Valentina Baiamonte,

Vincenzo Moschella,

Carlo Caltagirone,

Paolo Stanzione,

Alessandro Stefani

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.2234

Subject(s) - deep brain stimulation , pedunculopontine tegmental nucleus , parkinson's disease , subthalamic nucleus , epworth sleepiness scale , pedunculopontine nucleus , medicine , psychology , neuroscience , anesthesia , disease , polysomnography , central nervous system , apnea

Sleep disorders are frequent non-motor symptoms in Parkinson disease (PD), probably due to multifactorial pathogeneses including disease progression, dopaminergic drugs, or concomitant illness. In recent years, the pedunculopontine tegmental (PPTg) nucleus has been considered a surgical target for deep brain stimulation (DBS) in advanced PD patients. As it is involved in controlling the sleep-wake cycle, we investigated the long-lasting effects of PPTg-DBS on the sleep of five PD patients implanted in both the PPTg and the subthalamic nucleus (STN) by rating two subjective clinical scales for sleep: the Parkinson's Disease Sleep Scale (PDSS), and the Epworth Sleepiness Scale (ESS).

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