Open AccessMetabolic Effects of Chronic Sleep Restriction in Rats
Author(s) -
Ramalingam Vetrivelan,
Patrick M. Fuller,
Shigefumi Yokota,
Jun Lu,
Clifford B. Saper
Publication year - 2012
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.2200
Subject(s) - endocrinology , medicine , sleep restriction , ghrelin , leptin , sleep deprivation , weight loss , circadian rhythm , obesity , hormone
Chronic partial sleep loss is associated with obesity and metabolic syndrome in humans. We used rats with lesions in the ventrolateral preoptic area (VLPO), which spontaneously sleep about 30% less than intact rats, as an animal model to study the consequences of chronic partial sleep loss on energy metabolism.
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