State-Dependent Increase of Cortical Gamma Activity during REM Sleep after Selective Blockade of NR2B Subunit Containing NMDA Receptors | Zendy

Bernát Kocsis | Zendy

Open Access

State-Dependent Increase of Cortical Gamma Activity during REM Sleep after Selective Blockade of NR2B Subunit Containing NMDA Receptors

Author(s) -

Bernát Kocsis

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1972

Subject(s) - nmda receptor , blockade , neuroscience , receptor , sleep (system call) , protein subunit , medicine , psychology , endocrinology , anesthesia , chemistry , biochemistry , computer science , gene , operating system

Sub-anesthetic doses of NMDA receptor antagonists suppress sleep and elicit continuous high-power gamma oscillations lasting for hours. This effect is subunit-specific, as it was also seen after preferential blockade of the NR2A but not of the NR2B subunit-containing receptors. The objective of this study was to test whether NR2B receptor antagonists that do not induce lasting aberrant gamma elevation affect gamma activity during specific behaviors and states, including REM sleep, when gamma normally occurs.

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