Extracellular Levels of Lactate, but Not Oxygen, Reflect Sleep Homeostasis in the Rat Cerebral Cortex | Zendy

Michael B. Dash | Zendy; Giulio Toi | Zendy; Chiara Cirelli | Zendy

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Extracellular Levels of Lactate, but Not Oxygen, Reflect Sleep Homeostasis in the Rat Cerebral Cortex

Author(s) -

Michael B. Dash,

Giulio Toi,

Chiara Cirelli

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1950

Subject(s) - non rapid eye movement sleep , neuroscience of sleep , rapid eye movement sleep , neuroscience , sleep (system call) , glutamatergic , electroencephalography , slow wave sleep , medicine , endocrinology , sleep onset , glutamate receptor , psychology , biology , psychiatry , insomnia , computer science , operating system , receptor

It is well established that brain metabolism is higher during wake and rapid eye movement (REM) sleep than in nonrapid eye movement (NREM) sleep. Most of the brain's energy is used to maintain neuronal firing and glutamatergic transmission. Recent evidence shows that cortical firing rates, extracellular glutamate levels, and markers of excitatory synaptic strength increase with time spent awake and decline throughout NREM sleep. These data imply that the metabolic cost of each behavioral state is not fixed but may reflect sleep-wake history, a possibility that is investigated in the current report.

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