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Cortical GABA Levels in Primary Insomnia
Author(s) -
Peter Morgan,
Edward F. PaceSchott,
Graeme F. Mason,
Erica Forselius,
Madonna Fasula,
Gerald Valentine,
Gerard Sanacora
Publication year - 2012
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.1880
Subject(s) - primary insomnia , polysomnography , insomnia , psychology , sleep onset , sleep (system call) , wakefulness , zolpidem , neurology , anesthesia , medicine , psychiatry , audiology , sleep disorder , electroencephalography , computer science , operating system
GABA is increasingly recognized as an important neurotransmitter for the initiation and maintenance of sleep. We sought to measure cortical GABA content through proton magnetic resonance spectroscopy (MRS) in persons with and without primary insomnia, and relate brain GABA levels to polysomnographic sleep measures.

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