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Neuronal histamine shows diurnal rhythms in rodents and plays a major role in the maintenance of vigilance. No data are available on its diurnal fluctuation in humans, either in health or in neurodegenerative disorders such as Parkinson disease (PD), Alzheimer disease (AD), or Huntington disease (HD), all of which are characterized by sleep-wake disturbances.

sleep

Diurnal Fluctuation in Histidine Decarboxylase Expression, the Rate Limiting Enzyme for Histamine Production, and Its Disorder in Neurodegenerative Diseases