Diurnal Fluctuation in Histidine Decarboxylase Expression, the Rate Limiting Enzyme for Histamine Production, and Its Disorder in Neurodegenerative Diseases | Zendy

Ling Shan | Zendy; Michel A. Hofman | Zendy; Daniel J. van Wamelen | Zendy; Eus J.W. Van Someren | Zendy; Ai-Min Bao | Zendy; Dick F. Swaab | Zendy

Open Access

Diurnal Fluctuation in Histidine Decarboxylase Expression, the Rate Limiting Enzyme for Histamine Production, and Its Disorder in Neurodegenerative Diseases

Author(s) -

Ling Shan,

Michel A. Hofman,

Daniel J. van Wamelen,

Eus J.W. Van Someren,

Ai-Min Bao,

Dick F. Swaab

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1838

Subject(s) - histidine decarboxylase , histamine , limiting , enzyme , endocrinology , medicine , carboxy lyases , chemistry , histidine , biology , biochemistry , mechanical engineering , engineering

Neuronal histamine shows diurnal rhythms in rodents and plays a major role in the maintenance of vigilance. No data are available on its diurnal fluctuation in humans, either in health or in neurodegenerative disorders such as Parkinson disease (PD), Alzheimer disease (AD), or Huntington disease (HD), all of which are characterized by sleep-wake disturbances.

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