Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals | Zendy

Andrew Lim | Zendy; Lei Yu | Zendy; Madalena D. Costa | Zendy; Sue E. Leurgans | Zendy; Aron S. Buchman | Zendy; David A. Bennett | Zendy; Clifford B. Saper | Zendy

Open Access

Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals

Author(s) -

Andrew Lim,

Lei Yu,

Madalena D. Costa,

Sue E. Leurgans,

Aron S. Buchman,

David A. Bennett,

Clifford B. Saper

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1820

Subject(s) - cognitive impairment , rest (music) , fragmentation (computing) , cognition , psychology , gerontology , medicine , audiology , developmental psychology , neuroscience , biology , ecology

Aging is accompanied by changes in cognitive function, and changes in rest-activity patterns. Previous work has demonstrated associations between global rest-activity measures and cognitive performance on a number of tasks. Recently, we demonstrated that aging is associated with changes in the minute-to-minute fragmentation of rest-activity patterns in addition to changes in amounts of rest and activity. Given the body of experimental evidence linking sleep fragmentation with decrements in cognitive function in animals and humans, we hypothesized that increased fragmentation of rest-activity patterns would be associated with decreased cognitive function in older individuals.

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