Abnormal Sleep-Cardiovascular System Interaction in Narcolepsy with Cataplexy: Effects of Hypocretin Deficiency in Humans | Zendy

Daniela Grimaldi | Zendy; Giovanna CalandraBuonaura | Zendy; Federica Provini | Zendy; Patrizia Agati | Zendy; Giulia Pierangeli | Zendy; Christian Franceschini | Zendy; Giorgio Barletta | Zendy; Giuseppe Plazzi | Zendy; Pasquale Montagna | Zendy; Pietro Cortelli | Zendy

Open Access

Abnormal Sleep-Cardiovascular System Interaction in Narcolepsy with Cataplexy: Effects of Hypocretin Deficiency in Humans

Author(s) -

Daniela Grimaldi,

Giovanna CalandraBuonaura,

Federica Provini,

Patrizia Agati,

Giulia Pierangeli,

Christian Franceschini,

Giorgio Barletta,

Giuseppe Plazzi,

Pasquale Montagna,

Pietro Cortelli

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1738

Subject(s) - narcolepsy , circadian rhythm , cataplexy , wakefulness , medicine , endocrinology , morning , non rapid eye movement sleep , heart rate , polysomnography , sleep stages , psychology , autonomic nervous system , sleep (system call) , blood pressure , eye movement , modafinil , electroencephalography , apnea , neuroscience , psychiatry , computer science , operating system

Narcolepsy with cataplexy (NC) is associated with loss of hypocretin neurons in the lateral hypothalamus involved in the circadian timing of sleep and wakefulness, and many biologic functions including autonomic control. The authors investigated whether chronic lack of hypocretin signaling alters cardiovascular control during sleep in humans.

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