Developmental Changes in Glutamatergic Fast Synaptic Neurotransmission in the Dorsal Subcoeruleus Nucleus | Zendy

Christen Simon | Zendy; Abdallah Hayar | Zendy; Edgar GarcíaRill | Zendy

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Developmental Changes in Glutamatergic Fast Synaptic Neurotransmission in the Dorsal Subcoeruleus Nucleus

Author(s) -

Christen Simon,

Abdallah Hayar,

Edgar GarcíaRill

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1706

Subject(s) - glutamatergic , neuroscience , ampa receptor , excitatory postsynaptic potential , nmda receptor , kainic acid , neurotransmission , glutamate receptor , postsynaptic potential , agonist , rapid eye movement sleep , biology , endocrinology , medicine , chemistry , receptor , inhibitory postsynaptic potential , eye movement

The dorsal subcoeruleus nucleus (SubCD) is involved in the generation of rapid eye movement sleep (REM), a state distinguished by high-frequency EEG activity, muscle atonia, and ponto-geniculo-occipital (PGO) waves. Activation of the SubCD by injection of the glutamate (GLU) receptor agonist kainic acid (KA) produced a REM sleep-like state with muscle atonia. We tested the hypothesis that developmental changes in the GLU excitability of SubCD neurons could underlie the developmental decrease in REM sleep that occurs in the rat from postnatal days 10-30.

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