The BDNF Val66Met Polymorphism Modulates Sleep Intensity: EEG Frequency- and State-Specificity | Zendy

Valérie Bachmann | Zendy; Carina Klein | Zendy; Sereina Bodenmann | Zendy; Nikolaus Schäfer | Zendy; Wolfgang Berger | Zendy; Peter Brugger | Zendy; HansPeter Landolt | Zendy

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The BDNF Val66Met Polymorphism Modulates Sleep Intensity: EEG Frequency- and State-Specificity

Author(s) -

Valérie Bachmann,

Carina Klein,

Sereina Bodenmann,

Nikolaus Schäfer,

Wolfgang Berger,

Peter Brugger,

HansPeter Landolt

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1690

Subject(s) - non rapid eye movement sleep , wakefulness , sleep deprivation , slow wave sleep , psychology , electroencephalography , sleep spindle , neuroscience of sleep , sleep (system call) , medicine , k complex , sleep stages , rapid eye movement sleep , endocrinology , polysomnography , neuroscience , circadian rhythm , computer science , operating system

EEG slow waves are the hallmark of deep NREM sleep and may reflect the restorative functions of sleep. Evidence suggests that increased sleep slow waves after sleep deprivation reflect plastic synaptic processes, and that brain-derived neurotrophic factor (BDNF) is causally involved in their homeostatic regulation. The functional Val66Met polymorphism of the gene encoding pro-BDNF causes impaired activity-dependent secretion of mature BDNF protein. We investigated whether this polymorphism contributes to the pronounced inter-individual variation in sleep slow wave activity (SWA) in humans.

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