Olanzapine Causes a Leptin-Dependent Increase in Acetylcholine Release in Mouse Prefrontal Cortex | Zendy

Asheley B. Wathen | Zendy; Emily West | Zendy; Ralph Lydic | Zendy; Helen A. Baghdoyan | Zendy

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Olanzapine Causes a Leptin-Dependent Increase in Acetylcholine Release in Mouse Prefrontal Cortex

Author(s) -

Asheley B. Wathen,

Emily West,

Ralph Lydic,

Helen A. Baghdoyan

Publication year - 2012

Publication title -

sleep

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1686

Subject(s) - olanzapine , endocrinology , leptin , acetylcholine , medicine , prefrontal cortex , chemistry , schizophrenia (object oriented programming) , psychiatry , cognition , obesity

The atypical antipsychotic olanzapine is used effectively for treating symptoms of schizophrenia and bipolar disorder. Unwanted effects of olanzapine include slowing of the electroencephalogram (EEG) during wakefulness and increased circulating levels of leptin. The mechanisms underlying the desired and undesired effects of olanzapine are poorly understood. Sleep and wakefulness are modulated by acetylcholine (ACh) in the prefrontal cortex, and leptin alters cholinergic transmission. This study tested the hypothesis that olanzapine interacts with leptin to regulate ACh release in the prefrontal cortex.

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