Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation | Zendy

Cathalijn Leenaars | Zendy; Ruud N.J.M.A. Joosten | Zendy; Allard Zwart | Zendy; Hans Sandberg | Zendy; Emma Ruimschotel | Zendy; Maaike Hanegraaf | Zendy; Maurice Demattéis | Zendy; Matthijs G.P. Feenstra | Zendy; Eus J.W. Van Someren | Zendy

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Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

Author(s) -

Cathalijn Leenaars,

Ruud N.J.M.A. Joosten,

Allard Zwart,

Hans Sandberg,

Emma Ruimschotel,

Maaike Hanegraaf,

Maurice Demattéis,

Matthijs G.P. Feenstra,

Eus J.W. Van Someren

Publication year - 2012

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1624

Subject(s) - sleep deprivation , prefrontal cortex , neuroscience , sleep (system call) , sleep loss , task (project management) , psychology , task switching , cognition , computer science , management , economics , operating system

Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.

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