Effects of GF-015535-00, a Novel α1 GABAA Receptor Ligand, on the Sleep-Wake Cycle in Mice, with Reference to Zolpidem | Zendy

Christelle Anaclet | Zendy; Mei Zhang | Zendy; Chunmei Zhao | Zendy; Colette Buda | Zendy; Laurent Seugnet | Zendy; JianSheng Lin | Zendy

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Effects of GF-015535-00, a Novel α1 GABAA Receptor Ligand, on the Sleep-Wake Cycle in Mice, with Reference to Zolpidem

Author(s) -

Christelle Anaclet,

Mei Zhang,

Chunmei Zhao,

Colette Buda,

Laurent Seugnet,

JianSheng Lin

Publication year - 2011

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1596

Subject(s) - zolpidem , hypnotic , insomnia , sleep (system call) , slow wave sleep , electroencephalography , gabaa receptor , medicine , psychology , pharmacology , anesthesia , neuroscience , receptor , computer science , operating system

Novel, safe, and efficient hypnotic compounds capable of enhancing physiological sleep are still in great demand in the therapy of insomnia. This study compares the sleep-wake effects of a new α1 GABA(A) receptor subunit ligand, GF-015535-00, with those of zolpidem, the widely utilized hypnotic compound.

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