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Novel, safe, and efficient hypnotic compounds capable of enhancing physiological sleep are still in great demand in the therapy of insomnia. This study compares the sleep-wake effects of a new α1 GABA(A) receptor subunit ligand, GF-015535-00, with those of zolpidem, the widely utilized hypnotic compound.

Effects of GF-015535-00, a Novel α1 GABAA Receptor Ligand, on the Sleep-Wake Cycle in Mice, with Reference to Zolpidem