Identification of Causal Genes, Networks, and Transcriptional Regulators of REM Sleep and Wake | Zendy

Joshua Millstein | Zendy; Christopher J. Winrow | Zendy; Andrew Kasarskis | Zendy; Joseph R. Owens | Zendy; Lili Zhou | Zendy; Keith C. Summa | Zendy; Karrie Fitzpatrick | Zendy; Bin Zhang | Zendy; Martha Hotz Vitaterna | Zendy; Eric E. Schadt | Zendy; John J. Renger | Zendy; Fred W. Turek | Zendy

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Identification of Causal Genes, Networks, and Transcriptional Regulators of REM Sleep and Wake

Author(s) -

Joshua Millstein,

Christopher J. Winrow,

Andrew Kasarskis,

Joseph R. Owens,

Lili Zhou,

Keith C. Summa,

Karrie Fitzpatrick,

Bin Zhang,

Martha Hotz Vitaterna,

Eric E. Schadt,

John J. Renger,

Fred W. Turek

Publication year - 2011

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1378

Subject(s) - biology , genetics , sleep (system call) , quantitative trait locus , neuroscience , candidate gene , gene , computer science , operating system

Sleep-wake traits are well-known to be under substantial genetic control, but the specific genes and gene networks underlying primary sleep-wake traits have largely eluded identification using conventional approaches, especially in mammals. Thus, the aim of this study was to use systems genetics and statistical approaches to uncover the genetic networks underlying 2 primary sleep traits in the mouse: 24-h duration of REM sleep and wake.

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