Sleep Disturbance Impairs Stroke Recovery in the Rat
Author(s) -
Cristina Zunzunegui,
Bo Gao,
Ertugrul Cam,
Aleksandra Hodor,
Claudio L. Bassetti
Publication year - 2011
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.1252
Subject(s) - neurogenesis , stroke recovery , stroke (engine) , medicine , ischemia , neuroplasticity , angiogenesis , neuroscience , anesthesia , psychology , mechanical engineering , rehabilitation , engineering
There is a lack of experimental evidence to support the hypothesis that sleep may modulate stroke outcome as suggested by clinical observations. We have previously shown that sleep disturbance (SDis) over 3 days aggravates brain damage in a rat model of focal cerebral ischemia. The aim of this study is to further investigate effects of SDis on long-term stroke recovery and neuroplasticity as assessed by axonal sprouting, neurogenesis, and angiogenesis.
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