Urinary Leukotriene E4, Obesity, and Adenotonsillar Hypertrophy in Chinese Children with Sleep Disordered Breathing | Zendy

Yuelin Shen | Zendy; Zhifei Xu | Zendy; Kunling Shen | Zendy

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Urinary Leukotriene E4, Obesity, and Adenotonsillar Hypertrophy in Chinese Children with Sleep Disordered Breathing

Author(s) -

Yuelin Shen,

Zhifei Xu,

Kunling Shen

Publication year - 2011

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.1178

Subject(s) - medicine , polysomnography , overweight , leukotriene e4 , urinary system , obesity , systemic inflammation , obstructive sleep apnea , childhood obesity , apnea–hypopnea index , prospective cohort study , pediatrics , leukotriene , apnea , inflammation , asthma

Sleep disordered breathing (SDB) has been associated with increased inflammatory responses. Changes in the level of pro-inflammatory leukotrienes (LTs) may initiate or exacerbate pediatric SDB and may play a major role in end-organ morbidity. The objective of the study was to investigate the relationship of LT productions with severity of SDB, obesity, and adenotonsillar hypertrophy in children.

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