Open AccessREM Sleep Behavior Disorder in the Marmoset MPTP Model of Early Parkinson Disease
Author(s) -
Peternella S. Verhave,
Marjan J. Jongsma,
Roland M. van den Berg,
José C. Vis,
Raymond A.P. Vanwersch,
August B. Smit,
Eus J.W. Van Someren,
Ingrid H.C.H.M. Philippens
Publication year - 2011
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.1174
Subject(s) - marmoset , mptp , parkinson's disease , rem sleep behavior disorder , disease , sleep (system call) , neuroscience , psychology , rapid eye movement sleep , sleep disorder , medicine , electroencephalography , cognition , biology , computer science , operating system , paleontology
Sleep problems are a common phenomenon in most neurological and psychiatric diseases. In Parkinson disease (PD), for instance, sleep problems may be the most common and burdensome non-motor symptoms in addition to the well-described classical motor symptoms. Since sleep disturbances generally become apparent in the disease before motor symptoms emerge, they may represent early diagnostic tools and a means to investigate early mechanisms in PD onset. The sleep disturbance, REM sleep behavior disorder (RBD), precedes PD in one-third of patients. We therefore investigated sleep changes in marmoset monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP), the non-human primate model for idiopathic PD.
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