Upper Airway Reflexes are Preserved During Dexmedetomidine Sedation in Children With Down Syndrome and Obstructive Sleep Apnea | Zendy

Mohamed Mahmoud | Zendy; Stacey L. Ishman | Zendy; Keith McConnell | Zendy; Robert J. Fleck | Zendy; Sally R. Shott | Zendy; Goutham Mylavarapu | Zendy; Ephraim Gutmark | Zendy; Yuanshu Zou | Zendy; Rhonda D. Szczesniak | Zendy; Raouf S. Amin | Zendy

Open Access

Upper Airway Reflexes are Preserved During Dexmedetomidine Sedation in Children With Down Syndrome and Obstructive Sleep Apnea

Author(s) -

Mohamed Mahmoud,

Stacey L. Ishman,

Keith McConnell,

Robert J. Fleck,

Sally R. Shott,

Goutham Mylavarapu,

Ephraim Gutmark,

Yuanshu Zou,

Rhonda D. Szczesniak,

Raouf S. Amin

Publication year - 2017

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.6592

Subject(s) - dexmedetomidine , medicine , obstructive sleep apnea , sedation , anesthesia , reflex , airway , apnea , sleep (system call) , sleep apnea , computer science , operating system

The assessment of pharyngeal collapsibility is difficult to perform in children under normal sleep. An alternative is to perform the assessment under an anesthetic, such as dexmedetomidine (DEX), that induces non-rapid eye movement (NREM) sleep. The objectives of this study were to compare critical closing airway pressure (Pcrit) obtained during natural sleep to that obtained under DEX in patients with Down syndrome (DS) and persistent obstructive sleep apnea (OSA) and determine whether Pcrit measured under sedation predicts the severity of OSA.

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