Cataplexy with Normal Sleep Studies and Normal CSF Hypocretin: An Explanation? | Zendy

Panagis Drakatos | Zendy; Guy Leschziner | Zendy

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Cataplexy with Normal Sleep Studies and Normal CSF Hypocretin: An Explanation?

Author(s) -

Panagis Drakatos,

Guy Leschziner

Publication year - 2016

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.5604

Subject(s) - narcolepsy , cataplexy , excessive daytime sleepiness , multiple sleep latency test , medicine , context (archaeology) , cerebrospinal fluid , sleep (system call) , modafinil , sleep disorder , psychiatry , insomnia , biology , paleontology , computer science , operating system

Patients with narcolepsy usually develop excessive daytime sleepiness (EDS) before or coincide with the occurrence of cataplexy, with the latter most commonly associated with low cerebrospinal fluid (CSF) hypocretin-1 levels. Cataplexy preceding the development of other features of narcolepsy is a rare phenomenon. We describe a case of isolated cataplexy in the context of two non-diagnostic multiple sleep latency tests and normal CSF-hypocretin-1 levels (217 pg/mL) who gradually developed EDS and low CSF-hypocretin-1 (< 110 pg/mL).

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