Among Metabolic Factors, Significance of Fasting and Postprandial Increases in Acyl and Desacyl Ghrelin and the Acyl/Desacyl Ratio in Obstructive Sleep Apnea before and after Treatment | Zendy

Yuichi Chihara | Zendy; Takashi Akamizu | Zendy; Masanori Azuma | Zendy; Kimihiko Murase | Zendy; Yuka Harada | Zendy; Kiminobu Tanizawa | Zendy; Tomohiro Handa | Zendy; Toru Oga | Zendy; Michiaki Mishima | Zendy; Kazuo Chin | Zendy

Open Access

Among Metabolic Factors, Significance of Fasting and Postprandial Increases in Acyl and Desacyl Ghrelin and the Acyl/Desacyl Ratio in Obstructive Sleep Apnea before and after Treatment

Author(s) -

Yuichi Chihara,

Takashi Akamizu,

Masanori Azuma,

Kimihiko Murase,

Yuka Harada,

Kiminobu Tanizawa,

Tomohiro Handa,

Toru Oga,

Michiaki Mishima,

Kazuo Chin

Publication year - 2015

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.4942

Subject(s) - medicine , continuous positive airway pressure , postprandial , ghrelin , appetite , obstructive sleep apnea , leptin , endocrinology , body mass index , insulin , apnea , obesity , uvulopalatopharyngoplasty , insulin resistance , polysomnography , weight gain , hormone , body weight

There are reports suggesting that obstructive sleep apnea (OSA) may itself cause weight gain. However, recent reports showed increases in body mass index (BMI) following continuous positive airway pressure (CPAP) treatments. When considering weight changes, changes in humoral factors that have significant effects on appetite such as acyl (AG) and desacyl ghrelin (DAG), leptin, insulin, and glucose and their interactions, examples of which are AG/DAG and AG/insulin, are important. The aim of this study was to test the hypothesis that some appetite-related factors had a specific profile before and after CPAP treatment.

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