Plasma Total Ghrelin and Leptin Levels in Human Narcolepsy and Matched Healthy Controls: Basal Concentrations and Response to Sodium Oxybate | Zendy

Claire E. H. M. Donjacour | Zendy; Daniel Pardi | Zendy; N. Ahmad Aziz | Zendy; Marijke Frölich | Zendy; Ferdinand Roelfsema | Zendy; Sebastiaan Overeem | Zendy; Hanno Pijl | Zendy; Gert Jan Lammers | Zendy

Open Access

Plasma Total Ghrelin and Leptin Levels in Human Narcolepsy and Matched Healthy Controls: Basal Concentrations and Response to Sodium Oxybate

Author(s) -

Claire E. H. M. Donjacour,

Daniel Pardi,

N. Ahmad Aziz,

Marijke Frölich,

Ferdinand Roelfsema,

Sebastiaan Overeem,

Hanno Pijl,

Gert Jan Lammers

Publication year - 2013

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.2924

Subject(s) - narcolepsy , medicine , ghrelin , endocrinology , leptin , orexin , cataplexy , hormone , energy homeostasis , appetite , neuropeptide , obesity , modafinil , receptor , pharmacology

Narcolepsy is caused by a selective loss of hypocretin neurons and is associated with obesity. Ghrelin and leptin interact with hypocretin neurons to influence energy homeostasis. Here, we evaluated whether human hypocretin deficiency, or the narcolepsy therapeutic agent sodium oxybate, alter the levels of these hormones.

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