Gamakamide C and D as Two New Analogues of Bitter-Tasting Cyclic Peptide with Hydantoin Structure from Oyster Crassostrea gigas | Zendy

Jun Ho Jang | Zendy; Taesung Park | Zendy; JongSoo Lee | Zendy

Open Access

Gamakamide C and D as Two New Analogues of Bitter-Tasting Cyclic Peptide with Hydantoin Structure from Oyster Crassostrea gigas

Author(s) -

Jun Ho Jang,

Taesung Park,

JongSoo Lee

Publication year - 2015

Publication title -

fisheries and aquatic sciences

Language(s) - English

Resource type - Journals

eISSN - 2234-1757

pISSN - 2234-1749

DOI - 10.5657/fas.2015.0131

Subject(s) - chemistry , stereochemistry , hydantoin , fast atom bombardment , amino acid , oyster , peptide , mass spectrometry , biochemistry , biology , chromatography , fishery

Two new bitter-tasting cyclic peptides comprising six amino acids, namely gamakamide C and D, were isolated from cultured oysters Crassostrea gigas. Dimethylaminoazobenzene sulfonyl-amino acid analysis detected Val and Leu in gamakamide C and Ile and Leu in gamakamide D. The molecular formula of gamakamide C was determined as by high-resolution fast atom bombardment mass spectroscopy (HR FAB-MS) (), and that of gamakamide D was determined as by HR FAB-MS (). Comparison of amino acid analyses and fragment ions by MS/MS among gamakamide C, D, and E (known), the structures of gamakamide C and D were confirmed and , respectively.

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