IN SILICO PHARMACOKINETIC AND TOXICOLOGICAL STUDY OF DNASE INHIBITORS

Deoxyribonucleases (DNases) are the enzymes able to catalyze DNA hydrolysis and they play important roles in cell function, while DNase inhibitors are the compounds able to control or modify their activities. Using admetSAR, Toxtree and OSIRIS Property Explorer, we calculated and compared pharmacokinetic and toxicological properties of some natural and synthetic DNase inhibitors. Finally, we selected among the DNase inhibitors the ones with the most favorable toxicological and pharmacokinetical profiles. Acta Medica Medianae 2016;55(4):5-13.