Dapsone-induced methemoglobinemia: A case report | Zendy

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Dapsone-induced methemoglobinemia: A case report

Author(s) -

Ahmet Peker

Publication year - 2016

Publication title -

istanbul bilim university florence nightingale journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 2547-9466

pISSN - 2149-4401

DOI - 10.5606/fng.btd.2016.038

Subject(s) - methemoglobinemia , dapsone , dermatology , medicine , anesthesia

İletişim adresi: Dr. Ahmet Peker. Tepecik Eğitim ve Araştırma Hastanesi Hematoloji Kliniği, 35120 Tepecik, İzmir, Türkiye. Tel: 0232 444 35 60 e-posta: drahmet88@gmail.com ABSTRACT Dapsone is an aniline derivative belonging to the group of synthetic sulfones. Concerning the mechanism of action, dapsone combines both antibacterial and anti-inflammatory effects. Dapsone rarely induces oxidation of hemoglobin that reduces the enzyme activity of cytochrome b5 reductase located in erythrocytes resulting in significant methemoglobinemia. Herein we report a case of methemoglobinemia in a 36-year-old male patient using dapsone for eight years with discoid lupus diagnosis.

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