Comorbidities as risk factors of chronic kidney disease in HIV-infected persons | Zendy

Zofia Marchewka | Zendy; Aleksandra Szymczak | Zendy; Brygida Knysz | Zendy

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Comorbidities as risk factors of chronic kidney disease in HIV-infected persons

Author(s) -

Zofia Marchewka,

Aleksandra Szymczak,

Brygida Knysz

Publication year - 2015

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1186343

Subject(s) - medicine , kidney disease , diabetes mellitus , disease , pathogenesis , hyperlipidemia , population , immunology , endocrinology , environmental health

Significant survival prolongation in HIV-infected patients due to effective antiretroviral therapy is connected with increasing prevalence of chronic non-infective diseases in this population, among them chronic kidney disease. The pathogenesis of kidney disease in the setting of HIV includes conditions specific for HIV infection: direct effect of the virus, stage of immunodeficiency and drug toxicity. Chronic comorbidities, such as diabetes mellitus, hypertension, and hyperlipidemia, are additional significant risk factors of kidney disease. In HIV-infected individuals some distinct features of these conditions are observed, which are partly related to the virus and antiretroviral therapy. The article summarizes the effect of comorbidities on kidney function in HIV-infected persons.

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