Association between ins4436A in 11β-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population | Zendy

Paulina Hejduk | Zendy; Agata Sakowicz | Zendy; Tadeusz Pietrucha | Zendy

Open Access

Association between ins4436A in 11β-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population

Author(s) -

Paulina Hejduk,

Agata Sakowicz,

Tadeusz Pietrucha

Publication year - 2015

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1180646

Subject(s) - essential hypertension , 11β hydroxysteroid dehydrogenase type 1 , medicine , single nucleotide polymorphism , endocrinology , odds ratio , population , restriction fragment length polymorphism , biology , blood pressure , genotype , genetics , gene , dehydrogenase , enzyme , biochemistry , environmental health

Essential hypertension (EH) is the most common cardiovascular disease worldwide, and it has a strong genetic component. Cortisol homeostasis is an important factor in controlling blood pressure, and the availability of this hormone is regulated by 11βhydroxysteroid dehydrogenase type 1 enzyme (11βHSD1), which converts cortisone into cortisol.

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