Arsenic trioxide preferentially induces nonapoptotic cell deaths as well as actin cytoskeleton rearrangement in the CHO AA8 cell line | Zendy

Magdalena Izdebska | Zendy; Anna KlimaszewskaWiśniewska | Zendy; Dawid Lewandowski | Zendy; Jakub Marcin Nowak | Zendy; Maciej Gagat | Zendy; Alina Grzanka | Zendy

Open Access

Arsenic trioxide preferentially induces nonapoptotic cell deaths as well as actin cytoskeleton rearrangement in the CHO AA8 cell line

Author(s) -

Magdalena Izdebska,

Anna KlimaszewskaWiśniewska,

Dawid Lewandowski,

Jakub Marcin Nowak,

Maciej Gagat,

Alina Grzanka

Publication year - 2014

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1133098

Subject(s) - arsenic trioxide , acridine orange , propidium iodide , microbiology and biotechnology , chinese hamster ovary cell , programmed cell death , chemistry , apoptosis , cell culture , biology , biochemistry , genetics

The therapeutic effect of arsenic trioxide (ATO, As2O3) has been investigated for many years. However, the precise molecular mechanisms underlying the antitumor activity of ATO are still not fully understood, but seem to depend on cell types, dosage, and duration of exposure. The purpose of this study was to assess the actin cytoskeleton rearrangement during the cell death process induced by arsenic trioxide in the CHO AA8 cells. A better understanding the mechanisms of ATO-action is likely to lead to more rational use of this drug either as monotherapies or in combination with other anticancer agents.

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