Blocking of α1β1 and α2β1 adhesion molecules inhibits eosinophil migration through human lung microvascular endothelial cell monolayer | Zendy

Stanisława BazanSocha | Zendy; Joanna Żuk | Zendy; Hanna Plutecka | Zendy; Bogdan Jakieła | Zendy; Ewa Mlicka-Kowalczyk | Zendy; Bartosz Krzyżanowski | Zendy; Cezary Marcinkiewicz | Zendy; Lech Zaręba | Zendy; Jan G. Bazan | Zendy; Jacek Musiał | Zendy

Open Access

Blocking of α1β1 and α2β1 adhesion molecules inhibits eosinophil migration through human lung microvascular endothelial cell monolayer

Author(s) -

Stanisława BazanSocha,

Joanna Żuk,

Hanna Plutecka,

Bogdan Jakieła,

Ewa Mlicka-Kowalczyk,

Bartosz Krzyżanowski,

Cezary Marcinkiewicz,

Lech Zaręba,

Jan G. Bazan,

Jacek Musiał

Publication year - 2014

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1131696

Subject(s) - integrin , eosinophil , immunology , cell adhesion molecule , peripheral blood mononuclear cell , chemistry , endothelial stem cell , microbiology and biotechnology , receptor , biology , asthma , in vitro , biochemistry

In cell trafficking to the airways in asthma, among integrins the most important are those containing α4 and β2 subunits. We have previously shown that also blocking of collagen receptors, α1β1 and α2β1 integrins, inhibits transmigration of eosinophils of asthmatic subjects through a monolayer of skin microvascular endothelial cells seeded on collagen IV coated inserts. However, it was not clear whether this observation was limited to asthma or depended on the type of microvascular cell and collagen IV used as a base.

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