Preliminary study on application of urine amino acids profiling for monitoring of renal tubular injury using GLC-MS | Zendy

Maja Kazubek-Zemke | Zendy; Jacek Rybka | Zendy; Zofia Marchewka | Zendy; Wojciech Rybka | Zendy; Krzysztof Pawlik | Zendy; Anna Długosz | Zendy

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Preliminary study on application of urine amino acids profiling for monitoring of renal tubular injury using GLC-MS

Author(s) -

Maja Kazubek-Zemke,

Jacek Rybka,

Zofia Marchewka,

Wojciech Rybka,

Krzysztof Pawlik,

Anna Długosz

Publication year - 2014

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1128846

Subject(s) - urine , nephrotoxicity , chemistry , amino acid , valine , xenobiotic , leucine , chromatography , alanine , gas chromatography–mass spectrometry , mass spectrometry , biochemistry , toxicity , enzyme , organic chemistry

The early diagnosis of the nephrotoxic effect of xenobiotics and drugs is still an unsolved problem. Recent studies suggest a correlation between the nephrotoxic activity of xenobiotics and increased concentration of amino acids in urine. The presented study was focused on the application of GLC-MS method for amino acids profiling in human urine as a noninvasive method for monitoring of kidney condition and tubular injury level.

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