Urine uromodulin estimation in partial bladder outlet obstruction and cyclophosphamide-induced haemorrhagic cystitis models in rats | Zendy

Łukasz Dobrek | Zendy; Jolanta Kaszuba-Zwoińska | Zendy; Beata Skowron | Zendy; Agnieszka Baranowska | Zendy; Piotr Thor | Zendy

Open Access

Urine uromodulin estimation in partial bladder outlet obstruction and cyclophosphamide-induced haemorrhagic cystitis models in rats

Author(s) -

Łukasz Dobrek,

Jolanta Kaszuba-Zwoińska,

Beata Skowron,

Agnieszka Baranowska,

Piotr Thor

Publication year - 2014

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1121848

Subject(s) - tamm–horsfall protein , urine , excretion , urinary system , medicine , urology , distal convoluted tubule , cyclophosphamide , bladder outlet obstruction , endocrinology , kidney , chemotherapy , reabsorption , prostate , cancer

Uromodulin (UMOD) is a glycoprotein excreted by the thick ascending limb of the Henle's loop and distal convoluted tubule cells, playing various, yet still unclear roles. An abnormal urinary UMOD excretion is observed in many pathophysiological conditions. The aim of our study was to assess urine UMOD excretion in experimental partial bladder outlet obstruction (PBOO), reflecting BPH in humans, and in cyclophosphamide-induced haemorrhagic cystitis (CP-HC).

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