Dysregulation of the mTOR signaling pathway in the pathogenesis of autism spectrum disorders | Zendy

Bożena Gabryel | Zendy; Agata Kapałka | Zendy; W Sobczyk | Zendy; Krzysztof Łabuzek | Zendy; A.E. Gaweda | Zendy; Małgorzata Janas–Kozik | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Dysregulation of the mTOR signaling pathway in the pathogenesis of autism spectrum disorders

Author(s) -

Bożena Gabryel,

Agata Kapałka,

W Sobczyk,

Krzysztof Łabuzek,

A.E. Gaweda,

Małgorzata Janas–Kozik

Publication year - 2014

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1098143

Subject(s) - pi3k/akt/mtor pathway , autophagy , signal transduction , pathogenesis , autism , neuroscience , biology , actin cytoskeleton , translation (biology) , cytoskeleton , microbiology and biotechnology , medicine , cell , genetics , immunology , apoptosis , gene , psychiatry , messenger rna

Mammalian target of rapamycin (mTor) plays multiple role in central nervous system and is involved in regulation of cell viability, differentiation, transcription, translation, protein degradation, actin cytoskeletal organization and autophagy. Recent experimental and clinical studies reveal that disturbances of mTOR signaling are involved in the pathogenesis of autism spectrum disorders (ASD). This article reviews current data on the alteration in the mTOR transduction cascade, which may contribute to common neurobehavioral disorders typical for ASD. Moreover, the results of the latest experimental studies on the potential of mTOR inhibitors for the treatment of ASD are reviewed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research