The influence of a thyroxine supplemented diet on selected hepatic redox equilibrium markers, liver morphology and the serum lipid profile in rats treated with doxorubicin | Zendy

Agnieszka Korga-Plewko | Zendy; Jarosław Dudka | Zendy; Franciszek Burdan | Zendy; Lech Wronecki | Zendy; Jadwiga Sierocinska-Sawa | Zendy; Magdalena Iwan | Zendy; Agnieszka KorobowiczMarkiewicz | Zendy; Elżbieta Korobowicz | Zendy

Open Access

The influence of a thyroxine supplemented diet on selected hepatic redox equilibrium markers, liver morphology and the serum lipid profile in rats treated with doxorubicin

Author(s) -

Agnieszka Korga-Plewko,

Jarosław Dudka,

Franciszek Burdan,

Lech Wronecki,

Jadwiga Sierocinska-Sawa,

Magdalena Iwan,

Agnieszka KorobowiczMarkiewicz,

Elżbieta Korobowicz

Publication year - 2013

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/17322693.1038355

Subject(s) - doxorubicin , endocrinology , medicine , oxidative stress , steatosis , chemistry , glutathione , hormone , glycogen , reactive oxygen species , chemotherapy , enzyme , biochemistry

Cytotoxicity of doxorubicin (DOX) - an anticancer drug, mostly results from reactive oxygen species (ROS) generation. Some enzymes catalyzing this process and enzymes of antioxidant defense are regulated by iodothyronine hormones. Thus, disorders in iodothyronine hormone status may affect doxorubicin-induced redox imbalance and anabolic/catabolic disorders. The aim of this study was to evaluate the influence of doxorubicin and thyroxine (T4) associated treatment on liver morphology, markers of oxidative stress and plasma lipid parameters.

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