Bactericidal Activity of Octenidine to Various Genospecies of Borrelia burgdorferi, Sensu Lato Spirochetes in Vitro and in Vivo | Zendy

Stanisława Tylewska-Wierzbanowska | Zendy; Urszula Roguska | Zendy; Grażyna Lewandowska | Zendy; Tomasz Chmielewski | Zendy

Open Access

Bactericidal Activity of Octenidine to Various Genospecies of Borrelia burgdorferi, Sensu Lato Spirochetes in Vitro and in Vivo

Author(s) -

Stanisława Tylewska-Wierzbanowska,

Urszula Roguska,

Grażyna Lewandowska,

Tomasz Chmielewski

Publication year - 2017

Publication title -

polish journal of microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.312

H-Index - 34

eISSN - 2544-4646

pISSN - 1733-1331

DOI - 10.5604/01.3001.0010.7874

Subject(s) - borrelia burgdorferi , microbiology and biotechnology , borrelia , in vivo , biology , in vitro , immunology , antibody , biochemistry

The aim of our studies was to invent a reliable method for detection of the bactericidal activity of disinfectants against Borrelia burgdorferi in suspension (in vitro) and in cell line cultures (in vivo). In the suspension method, 0.01% octenidine at 20°C and 35°C was bactericidal to Borrelia afzeli; Borrelia garini, B. burgdorferi sensu stricto after 5 minutes treatment. Increase of the temperature to 35°C speed up the bactericidal effect to 1 minute. The bactericidal action of octenidine towards B. burgdorferi spirochetes growing in fibroblasts was less effective and needed a longer time to kill them than in the suspension.

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